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4-CN-BINACA-ADB for sale (also known as CUMYL-CYBINACA or SGT-78) is an indazole-3-carboxamide based synthetic cannabinoid that has been offered online as a designer drug. It is a strong agonist for cannabinoid receptors CB1 and CB2, having in vitro EC50 values of 0.58 nM and 6.12 nM, respectively. In mice, 4-CN-BINACA-ADB induces hypothermic and pro-convulsant effects through the CB1 receptor, and anecdotal reports indicate it has an active dosage of roughly 0.1 mg in humans.
4-CN-BINACA-ADB online is metabolized to create cyanide, raising concerns regarding liver damage. There is one recorded instance of hyperthermia, rhabdomyolysis, and renal failure related to its usage.
4-CN-BINACA-ADB legal originates, for example, SGT-78 in a New Zealand patent from 2014 documenting the synthesis of cannabinoids for “treating pain and nausea, stimulating appetite, and causing a favorable mood change,” and its synthetic technique is similar to those recorded for similar compounds.
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4-CN-BINACA-ADB for sale is not for human or animal consumption and is exclusively for research purposes.
CB1 receptor agonist 4-CN-BINACA-ADB has a potency and effectiveness comparable to that of CP 55,940 in vitro, as is the case with numerous cumylamine-derived SCRAs. At CB2 receptors, it likewise has a high affinity and high effectiveness. While nitrile SCRA AM-2232 has a higher affinity for binding CB1 receptors than its 5-fluoropentyl analog AM-2201, 4-CN-BINACA-ADB has a similar affinity and functional activity for binding CB1 receptors as its 5-fluoropentyl analog 5F-CUMYL-PINACA. As a result, it seems that the nitrile alteration only increases CB1 receptor binding affinity in certain situations, likely requiring interaction with other structural features of SCRA molecules.
Approved use of 4-CN-BINACA-ADB
Note that no known jurisdiction has authorized 4-CN-BINACA-ADB as medication, therapy, or dietary supplement. It is available for research purposes and should not be administered to people or used in any in vivo chemical studies. In vitro research and a sample calibration is the sole uses for this product.
History of Misuse
Synthetic cannabis blends have been found to include chemicals such as 4-CN-BINACA-ADB online since at least 2015, when they were first discovered in Japan. However, it is unclear which synthetic chemical was responsible for the illnesses or injuries that resulted in the hospitalization of these users.
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