Exploring the Effects of alpha-Pyrrolidinohexiophenone (α-PHP)

Alpha-Pyrrolidinohexiophenone, also known as α-PHP, is a synthetic stimulant drug that belongs to the cathinone class. It is a research chemical that has gained popularity in recent years as a legal high, often sold under the name “flakka” or “gravel.” While it is not as well-known as other drugs in its class, such as bath salts or mephedrone, α-PHP has been linked to a number of concerning effects and has been the subject of much research.

Chemical Composition

Chemical structure of alpha-Pyrrolidinohexiophenone

by Ricardo Gomez Angel (https://unsplash.com/@rgaleriacom)

Alpha-Pyrrolidinohexiophenone is a synthetic compound that is structurally similar to other cathinones, such as alpha-PVP and alpha-PHP. It is a white or off-white crystalline powder that is often sold in capsule or tablet form. The chemical formula for α-PHP is C16H23NO, and it has a molecular weight of 245.37 g/mol.

Effects on the Body

The effects of α-PHP on the body are similar to other stimulant drugs, such as cocaine and amphetamines. It increases the levels of dopamine, norepinephrine, and serotonin in the brain, leading to feelings of euphoria, increased energy, and heightened alertness. Users may also experience increased heart rate, blood pressure, and body temperature. Some users have reported experiencing intense cravings for the drug, leading to compulsive use and potential addiction.

Potential Risks and Side Effects

While α-PHP is marketed as a legal high, it is important to note that it is not approved for human consumption and has not been thoroughly studied. As a result, the potential risks and side effects of using this drug are not fully understood. However, some studies have linked α-PHP to a number of concerning effects, including:

  • Psychotic episodes
  • Aggressive behavior
  • Paranoia
  • Hallucinations
  • Seizures
  • Kidney damage
  • Cardiovascular issues
  • Respiratory problems


In many countries, α-PHP is considered a controlled substance and is illegal to possess, sell, or use. However, due to its relatively recent emergence and lack of widespread knowledge, it may still be available for purchase online or in certain stores. It is important to note that even if it is legal in your area, the potential risks and side effects of using this drug should not be taken lightly.


While α-PHP may be marketed as a legal high, it is important to understand the potential risks and side effects associated with this drug. As a research chemical, it has not been thoroughly studied and its effects on the body are not fully understood. It is always important to approach any substance with caution and to prioritize your health and safety above any potential high. If you or someone you know is struggling with substance abuse, seek help from a medical professional or a trusted support system.

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